Liposome-entrapped DNA oral vaccines

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United States of America Patent

PATENT NO 7008791
SERIAL NO

10089312

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Abstract

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An oral vaccine contain liposomes and complexed or, preferably entrapped, DNA operatively encoding an antigen in which the liposomes are formed from components including cationic compounds and zwitterionic phospholipids. The hydrophobic groups within the liposome forming components must include at least one group which is saturated. This is believed to raise the transition temperature, rendering the liposomes more stable when delivered orally. The compositions have been found to give detectable increased in IgA levels, secreted immunoglobulins of importance in efficacious oral vaccine delivery.

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Patent Owner(s)

Patent OwnerAddress
LIPOXEN TECHNOLOGIES LIMITEDLONDON BIOSCIENCE INNOVATION CENTER 2 ROYAL COLLEGE STREET LONDON NW1 0NH

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Gregoriadis, Gregory London, GB 52 366
Perrie, Yvonne Birmingham, GB 3 19

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