Variants of traf2 which act as an inhibitor of tnf-alpha (tnfα) signaling pathway
Number of patents in Portfolio can not be more than 2000
United States of America Patent
Stats
-
Feb 14, 2006
Grant Date -
N/A
app pub date -
Apr 6, 2000
filing date -
Apr 30, 1999
priority date (Note) -
Expired
status (Latency Note)
Importance
Abstract
The present invention relates to variants of TRAF2 which demonstrate the ability to inhibit the TNF α signaling path-way. In particular, applicants have isolated a splice variant of TRAF2 referred to hereinafter as 'TRAF2 truncated' or 'TRAF2TR' and a TRAF2 expression construct with enhanced dominant negative properties, hereafter referred to as 'TRAF2 truncated-deleted' or 'TRAF2TD'. Both TRAF2TR and TRAF2TD have the ability to inhibit the TNF α signaling pathway and in TRAF2TD, this ability is greatly enhanced, greatly reducing the response to TNF α binding.
First Claim
Family
International Classification(s)
Cited Art Landscape
Patent Citation Ranking
Recipient Email Address
Recipient Email Address
Comment
Recipient Email Address
Add to Portfolio(s)
To add this patent to one, or more, of your portfolios, simply click the add button.
This Patent is in these Portfolios:
Add to additional portfolios:
Last Refreshed On:
Changes done successfully