Inhibitors of receptor activator of NF-κB and uses thereof
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United States of America Patent
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Feb 14, 2006
Grant Date -
Jan 16, 2003
app pub date -
May 10, 2002
filing date -
May 11, 2001
priority date (Note) -
Expired
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Abstract
The present invention provides a RANK (receptor activator of NF-κB) inhibitor consisted of a TRAF-6 (TNF receptor-associated factor-6) binding domain attached to a leader sequence. The peptide inhibitor inhibits RANKL (RANK ligand)-mediated osteoclast differentiation, thus indicating that targeted disruption of interaction between RANK and TRAF6 may prove useful as a therapeutic for metabolic bone disorders, leukemia, arthritis, and metastatic cancer of the bone.
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