Thiol-based NAALADase inhibitors
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United States of America Patent
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Jan 31, 2006
Grant Date -
Apr 21, 2005
app pub date -
Oct 7, 2004
filing date -
Jan 17, 2001
priority date (Note) -
Expired
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Abstract
This invention relates to new compounds, pharmaceutical compositions and diagnostic kits comprising such compounds, and methods of using such compounds for inhibiting NAALADase enzyme activity, detecting diseases where NAALADase levels are altered, effecting neuronal activity, effecting TGF-β activity, inhibiting angiogenesis, and treating glutamate abnormalities, diabetic neuropathy, pain, compulsive disorders, prostate diseases, cancers and glaucoma.
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