Methods for diagnosis and treatment of chronic immune diseases
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United States of America Patent
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Jan 24, 2006
Grant Date -
Jan 23, 2003
app pub date -
Jun 17, 2002
filing date -
Jun 20, 2001
priority date (Note) -
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Abstract
Methods are provided for diagnosing/characterizing chronic immune disease activity in a subject. In the subject methods, a sample is obtained from a subject suspected of having or known to have a chronic immune disease. The sample is then assayed for the presence and amount of intact (i.e., native) p53 protein and/or fragments thereof. The assay results are used to diagnose the presence of chronic immune disease and/or characterize chronic immune disease activity in a subject, and/or to determine appropriate treatments protocols. Also provided by the subject invention are methods of treating chronic immune disease conditions by enhancing p53 activity. Also provided by the subject invention are kits for practicing the methods.
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