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United States of America Patent
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Jan 24, 2006
Grant Date -
N/A
app pub date -
Dec 9, 1999
filing date -
Dec 9, 1998
priority date (Note) -
Expired
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Abstract
Particles of an amino acid such as leucine may be formed from an amino acid vapor, for example by aerosol condensation, or by spray drying. The amino acid particles have a bulk density of not more than 0.1 gcm-3 or have a mass median aerodynamic diameter of not more than 10 μm or are in the form of flakes having a thickness of not more than 100 μm. The inclusion of the particles of amino acid in powder for use in dry powder inhalers has been found to improve the respirable fraction of the active material in the powder.
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