Anaerobe targeted enzyme-mediated prodrug therapy

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United States of America Patent

PATENT NO 6984513
SERIAL NO

10158976

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Abstract

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Recombinant anaerobic bacterial compositions that under anaerobic conditions present in a solid tumor and produce an enzyme capable of catalyzing the conversion of a prodrug to its cytotoxic product in situ are described. Methods of treating tumors using the composition are also described.

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Patent Owner(s)

Patent OwnerAddress
MICROBIOLOGICAL RESEARCH AUTHORITY (MRA) ACTING THROUGH THE CENTRE FOR APPLIED MICROBIOLOGY & RESEARCH (CAMR)PORTON DOWN SALISBURY WILTSHIRE SP4 0JG

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Brown, John M Redwood City, CA 30 577
Giaccia, Amato J Stanford, CA 30 262
Liu, Shie-Chau Redwood City, CA 1 71
Minton, Nigel P Salisbury, GB 9 165

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