Human MEKK proteins, corresponding nucleic acid molecules, and uses therefor
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United States of America Patent
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Dec 13, 2005
Grant Date -
Oct 10, 2002
app pub date -
Oct 31, 2001
filing date -
Mar 16, 1998
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Expired
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Abstract
Isolated nucleic acid molecules encoding human MEKK proteins, and isolated MEKK proteins, are provided. The invention further provides antisense nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals carrying a human MEKK transgene. The invention further provides human MEKK fusion proteins and anti-human MEKK antibodies. Methods of using the human MEKK proteins and nucleic acid molecules of the invention are also disclosed, including methods for detecting human MEKK activity in a biological sample, methods of modulating human MEKK activity in a cell, and methods for identifying agents that modulate the activity of human MEKK.
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