Method for producing a controlled-release preparation
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United States of America Patent
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Dec 13, 2005
Grant Date -
Nov 8, 2001
app pub date -
Mar 29, 2001
filing date -
Mar 31, 2000
priority date (Note) -
Expired
status (Latency Note)
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Abstract
The invention concerns a method for producing a controlled-release pharmaceutical preparation with a particle-containing coating, the coating being derived from an aqueous dispersion of a film-forming water insoluble polymer and a water soluble pore-forming agent. By suspending, instead of dissolving the pore-forming agent, the resulting coating will contain particles of the pore-formers with a predetermined size that creates, when disintegrated or dissolved in the body fluid, canals or a network of pores through the polymer film. Due to this network, the film will get a good mechanical stability and are left intact after the release of the drug.
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