Thiazepinyl hydroxamic acid derivatives as matrix metalloproteinase inhibitors
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United States of America Patent
Stats
-
Nov 22, 2005
Grant Date -
Jul 17, 2003
app pub date -
Feb 20, 2001
filing date -
Feb 21, 2000
priority date (Note) -
Expired
status (Latency Note)
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Abstract
A compound of formula (I) in which R1 is halo, lower alkoxy, optionally substituted aryl, optionally substituted aryloxy, optionally substituted heterecyclic group or optionally substituted lower alkynyl, R2 is amidated carboxy, R3 is hydrogen or acyl, Ar is aryl or heterocyclic group, X is thia, sulfinyl or sulfonyl, Y and Z are each lower alkylene, m and n are each an integer of 0 to 2, and a salt thereof, useful as inhibitors of matrix metalloproteinases (MMP) or the production of tumor necrosis factor α (TNF α) ##STR1##
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Cited Art Landscape
Patent Citation Ranking
- 5 Citation Count
- A61K Class
- 9.11 % this patent is cited more than
- 20 Age
