7-carboxy-flavone derivatives preparation method and therapeutic use
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United States of America Patent
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Nov 15, 2005
Grant Date -
Mar 25, 2004
app pub date -
Oct 5, 2001
filing date -
Oct 6, 2000
priority date (Note) -
Expired
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Abstract
The invention concerns novel flavone and isoflavone derivatives of formulae (Ia) and (Ib) wherein: X represents a group of formula —COOR, or —PO(OR)2; R represents a hydrogen atom or an alkaline or alkaline-earth metal, or a lower alkyl group; R1 represents a hydroxy group, a lower alkoxy group or an acyloxy group; R2 and R3, identical or different, represent a hydrogen or halogen atom, or a trifluoromethyl group, a trichloromethyl group, a hydroxy group, an alkoxy group or an acyloxy group comprising 1 to 5 carbon atoms, or R2 and R3 can combine to form an alkylene dioxy group. The invention is useful for rheumatic diseases.
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