Polynucleotide
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United States of America Patent
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Nov 15, 2005
Grant Date -
Mar 27, 2003
app pub date -
Aug 21, 2002
filing date -
Jul 21, 1998
priority date (Note) -
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Abstract
The present invention relates to a polynucleotide comprising a ubiquitous chromatin opening element (UCOE) which is not derived from 13. The present invention also relates to a vector comprising the polynucleotide sequence, a host cell comprising the vector, use of the polynucleoticle, vector or host cell in therapy and in an assay, and a method of identifying UCOEs. The UCOE opens chromatin or maintains chromatin in an open state and facilitates reproducible expression of an operably-linked gene in cells of at least two different tissue types.
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