Treatment of neovascularization disorders with squalimine
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United States of America Patent
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Nov 8, 2005
Grant Date -
Aug 7, 2003
app pub date -
Nov 2, 2001
filing date -
Jun 7, 1995
priority date (Note) -
Expired
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Abstract
Aminosterol compounds are described that are useful as inhibitors of the sodium/proton exchanger (NHE). Methods of using such aminosterols compounds are also enclosed, including those employing compounds that are inhibitors of a spectrum of NHEs as well as those using compounds that are inhibitors of only one specific NHE. Advantageous screening techniques and assays for evaluating a compound's therapeutic activity are also disclosed.
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