Application of glucose transport mutants for production of aromatic pathway compounds
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United States of America Patent
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Nov 8, 2005
Grant Date -
Oct 24, 2002
app pub date -
Sep 30, 1997
filing date -
May 5, 1995
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Expired
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Abstract
This invention describes methods for enhancing carbon flow into a pathway of a host cell to enhance the biosynthetic production of compounds therefrom, the host cells being selected based on being phenotypically Pts-/glucose+. Such host cells are capable of transporting glucose without consuming PEP, resulting in conservation of PEP which can be re-directed into the pathway in order to enhance the production of desired compounds along the pathway. Pts-/glucose+ mutants have been shown to be advantageous for the enhanced production of the aromatic amino acids.
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