Carbamic acid compounds comprising an ether linkage as HDAC inhibitors
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United States of America Patent
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Nov 1, 2005
Grant Date -
Oct 7, 2004
app pub date -
Jul 28, 2003
filing date -
Sep 29, 2000
priority date (Note) -
Expired
status (Latency Note)
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Abstract
This invention pertains to certain active carbamic acid compounds which inhibit HDAC activity and which have the following formula: ##STR1## wherein: A is an aryl group; Q.sup.1 is a covalent bond or an aryl leader group; J is an amide linkage selected from: --NR.sup.1 C(.dbd.O)-- and --C(.dbd.O)NR.sup.1 --; R.sup.1 is an amido substituent; X is an ether heteroatom, and is --O-- or --S--; and, R.sup.2 and R.sup.3 are each independently an ether group; and pharmaceutically acceptable salts, solvates, amides, esters, ethers, chemically protected forms, and prodrugs thereof. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit HDAC, and, e.g., to inhibit proliferative conditions, such as cancer and psoriasis.
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