Compositions and methods for use in targeting vascular destruction
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United States of America Patent
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Oct 18, 2005
Grant Date -
Jun 12, 2003
app pub date -
Aug 14, 2002
filing date -
Feb 18, 1999
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Abstract
Treatment of warm-blooded animals having a tumor or non-malignant hypervascularation, by administering a sufficient amount of a cytotoxic agent formulated into a phosphate prodrug form having substrate specificity for microvessel phosphatases, so that microvessels are destroyed preferentially over other normal tissues, because the less cytotoxic prodrug form is converted to the highly cytotoxic dephosphorylated form.
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