Methods and apparatus for improved laser desorption ionization tandem mass spectrometry
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United States of America Patent
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Sep 20, 2005
Grant Date -
May 29, 2003
app pub date -
Jun 26, 2002
filing date -
Nov 27, 2001
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Abstract
Laser desorption/ionization tandem mass spectrometer instruments that include immediate post source collisional cooling are presented, as are analytical methods that employ such instruments to achieve increased sensitivity and ion yield. Also presented are laser desorption/ionization mass spectrometry methods that improve sensitivity and relative ion yield by combining affinity capture probes with matrices having low melting point energy absorbing molecules combined with alkali metal scavengers.
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