Design of artificial genes for use as controls in gene expression analysis systems
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United States of America Patent
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Sep 13, 2005
Grant Date -
Sep 18, 2003
app pub date -
May 7, 2002
filing date -
May 7, 2001
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Expired
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Abstract
Method of producing controls for use in gene expression analysis systems such as macroarrays, real-time PCR, northern blots, SAGE and microarrays. The controls are generated either from near-random sequence of DNA, or from inter- or intragenic regions of a genome. Ten specific control sequences are also disclosed. Also presented are methods of using these controls, including as negative controls, positive controls, and as calibrators of a gene expression analysis system.
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