5-substituted 2-aryl-4-pyrimidinones
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United States of America Patent
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Sep 13, 2005
Grant Date -
May 2, 2002
app pub date -
Jul 18, 2001
filing date -
Jul 18, 2000
priority date (Note) -
Expired
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Abstract
Arylpyrimidinone compounds that act as selective modulators of CRF 1 receptors are provided. These compounds are useful in the treatment of a number of CNS and periphereal disorders, particularly stress, anxiety, depression, cardiovascular disorders, and eating disorders. Methods of treatment of such disorders and well as packaged pharmaceutical compositions are also provided. Compounds of the invention are also useful as probes for the localization of CRF receptors and as standards in assays for CRF receptor binding. Methods of using the compounds in receptor localization studies are given.
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