Regioselective and stereoselective oxidation of fused ring systems useful for the preparation of aminosterols
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United States of America Patent
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Aug 23, 2005
Grant Date -
Sep 11, 2003
app pub date -
Oct 11, 2002
filing date -
Apr 12, 2000
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Abstract
An efficient method for the synthesis of aminosterol compounds such as squalamine and compound 1436 is described. A method of the invention provides for regioselective oxidation and regioselective sulfonation of a fused ring system. The fused ring base can be, for example, a steroid ring base. The aminosterol compounds are effective as, for example, antibiotics, antiangiogenic agents and NHE3 inhibitors.
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