Antiuracil monoclonal antibody
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United States of America Patent
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Aug 9, 2005
Grant Date -
N/A
app pub date -
Oct 18, 2000
filing date -
Oct 19, 1999
priority date (Note) -
Expired
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Abstract
A monoclonal antibody which reacts strongly with uracil and thymine but scarcely with N-carbamyl-β-alanine; a hybridoma producing this monoclonal antibody; a method of immunochemically assaying uracil or thymine characterized by using the above-described monoclonal antibody; and diagnostics for DPD deficiency containing the above monoclonal antibody. Because of high sensitivity and specific reaction with uracil and thymine, the above-described monoclonal antibody enables convenient, quick, and selective assaying of uracil and thymine in a sample. The antibody is useful in screening patients with DPD deficient cancer with contraindication to the administration of pyrimidine fluoride-based antitumor agents.
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