Chemically activated carboxypolysaccharides and methods for use to inhibit adhesion formation and promote hemostasis
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United States of America Patent
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Aug 2, 2005
Grant Date -
Oct 30, 2003
app pub date -
Apr 30, 2002
filing date -
Apr 30, 2002
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Abstract
Carboxypolysaccharides (CPS) including carboxymethyl cellulose and their derivatives are provided that can be made into sponges, gels, membranes, particulates and other forms, for a variety of antiadhesion, antithrombogenic, drug delivery and/or hemostatic applications during surgery and pharmacological therapeutics. CPSs derivatized with primary amines can be used alone or in combination with poly(ethylene glycol) and poly(ethylene oxides) and other poly(alkylene oxides) to form materials having improved drug delivery, antiadhesion, and hemostatic uses. Applications include other types of chemical modifications of CPS to provide hydrogen, ionic, Van der Walls interactions and/or covalent bonding with drugs, biologicals and other therapeutic or diagnostic purposes.
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