Controlled release bead, a method of producing the same and multiple unit formulation comprising it
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United States of America Patent
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Jun 28, 2005
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N/A
app pub date -
Nov 11, 1999
filing date -
Nov 11, 1998
priority date (Note) -
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Abstract
A controlled release bead comprises: (i) a core unit of a substantially water-soluble or water-swellable inert material; (ii) a first layer on the core unit of a substantially water-insoluble polymer; (iii) a second layer covering the first layer and containing an active ingredient; and (iv) a third layer of polymer on the second layer effective for controlled release of the active ingredient, wherein the first layer is adapted to control water penetration into the core. A method of producing the controlled release bead is also disclosed.
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