Inhibitors for de novo-RNA polymerases and methods of identifying targets for same
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United States of America Patent
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Jun 14, 2005
Grant Date -
Oct 2, 2003
app pub date -
Dec 27, 2002
filing date -
Jan 4, 2002
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Expired
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Abstract
A polymerase inhibitor has first moiety coupled to a second moiety via an optional linker in which the first moiety binds to an initiation nucleotide binding site of a polymerase and forms at least two hydrogen bonds with an RNA template strand that is associated with the polymerase, and in which the second moiety comprised a compound that binds to a site proximal to the nucleotide binding site of the polymerase and thereby increases the affinity of the polymerase inhibitor to the polymerase.
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