N-acetylcolchinol-O-phosphate combination therapies with vascular damaging activity
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United States of America Patent
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Jun 14, 2005
Grant Date -
Sep 4, 2003
app pub date -
Mar 27, 2001
filing date -
Mar 31, 2000
priority date (Note) -
Expired
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Abstract
The invention relates to a method for the production of a vascular damaging effect in a warm-blooded animal such as a human, which comprises administering to said animal an effective amount of ZD6126 or a pharmaceutically acceptable salt thereof, before, after or simultaneously with an effective amount of one of the following therapies: i) ionizing radiation; ii) a platinum anti-tumor agent; and iii) a taxane. The invention also relates to the use of ZD6126 and one of the above therapies in the manufacture of a medicament for use in the production of a vascular damaging effect in a warm-blooded animal such as a human and to pharmaceutical compositions and kits each comprising ZD6126 and one of a platinum anti-tumor agent and a taxane ##STR1##
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