Transgenic Drosophila melanogaster expressing a β42 in the eye
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United States of America Patent
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May 31, 2005
Grant Date -
Nov 21, 2002
app pub date -
Sep 27, 2001
filing date -
Sep 29, 2000
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Expired
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Abstract
Transgenic flies displaying altered phenotypes due to expression of the Abeta and C99 portions of the human APP gene are disclosed. Use of these flies in a method to identify Drosophila genes and the human homologs of these Drosophila genes, that are potentially involved in Alzheimer's Disease, is also disclosed. The use of said human homologs as drug targets for the development of therapeutics to treat Alzheimer's Disease and other conditions associated with defects in the APP pathway, as well as pharmaceutical compositions comprising substances directed to these genes, are also disclosed.
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