Platinum complexes as antitumor agents
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United States of America Patent
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May 17, 2005
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N/A
app pub date -
Oct 4, 2000
filing date -
Oct 4, 2000
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Abstract
The present invention relates to platinum antitumor drugs. In particular, it relates to platinum complexes having formula Ia or Ib ##STR1## or a pharmaceutically acceptable salt thereof wherein: each A is independently an anion; each B is independently halo, hydroxy, carboxylate, carbamate or a carbonate ester, Z is a substituted 5- or 6-membered, heterocyclic moiety wherein at least one substituent sterically hinders access of the Pt atom to a DNA strand of a tumor cell, and wherein Z is other than pyridine; and X is NH3 or mono- or dialkyl substituted NH3. which are active against cancer cells and have improved aqueous solubility and activity.
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