Frequency correction for drop size control
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United States of America Patent
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May 17, 2005
Grant Date -
Mar 25, 2004
app pub date -
Sep 20, 2002
filing date -
Sep 20, 2002
priority date (Note) -
Expired
status (Latency Note)
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Abstract
The present invention provides a method and device for the acoustic ejection of fluid droplets having a constant drop size from fluid-containing reservoirs having varying fluid heights contained therein without the need for repositioning the acoustic ejector in the z direction by adjusting the RF frequency and amplitude. In one embodiment, the device is comprised of: a plurality of reservoirs each adapted to contain a fluid; an ejector comprising a means for generating acoustic radiation, means for controlling the RF frequency and amplitude used to generate the acoustic radiation, means for focusing the acoustic radiation at a focal point near the fluid surface in each of the reservoirs; and a means for positioning the ejector in acoustically coupled relationship to each of the reservoirs. The invention is useful in a number of contexts, particularly in the preparation of biomolecular arrays.
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