Urinary assay for measuring bone resorption
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United States of America Patent
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May 3, 2005
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N/A
app pub date -
Jan 17, 2003
filing date -
Nov 6, 1987
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Abstract
A method for assaying bone resorption rates which consists of quantitating the concentration of peptide fragments derived from bone collagen, found in a body fluid is disclosed. The method includes immunometric assay, fluorometric assay and electrochemical titration. The structure of specific peptide fragments having 3-hydroxypyridinium cross-links found in urine of Paget's disease patients and procedures for making monoclonal antibodies is described.
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