Dielectrophoretic separation and immunoassay methods on active electronic matrix devices
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United States of America Patent
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May 3, 2005
Grant Date -
Aug 7, 2003
app pub date -
Feb 6, 2002
filing date -
Feb 6, 2002
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Expired
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Abstract
This invention relates to devices and methods for performing active, multi-step molecular and biological sample preparation and diagnostic analyses employing immunochemical techniques. It relates generally to bioparticle separation, bioparticle enrichment, and electric field-mediated immunochemical detection on active electronic matrix devices utilizing AC and DC electric fields. More specifically, the invention relates to devices and methods for sample preparation/manipulation, immunoimmobilization, and immunoassays, all of which can be conducted on one or more active electronic chip devices within a single system. These manipulations are useful in a variety of applications, including, for example, detection of pathogenic bacteria and biological warfare agents, point-of-care diagnostics, food or medical product quality control assays, and other biological assays.
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