2'-Substituted RNA preparation
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United States of America Patent
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Apr 26, 2005
Grant Date -
N/A
app pub date -
Dec 5, 2001
filing date -
Mar 19, 1999
priority date (Note) -
Expired
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Abstract
A process for the preparation of a compound of formula (1): ##STR1## is provided, which comprises the reaction a compound of formula (2): ##STR2## with a compound of formula Al(OR).sub.3 under substantially anhydrous conditions. X, and X.sup.1 are each independently H or a protecting group, B is a base; R is an alkyl, alkoxyalkyl, alkenyl or alkynyl group, each of which may be optionally substituted, and L is a leaving group.
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