Benzimidazole derivatives
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United States of America Patent
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Apr 26, 2005
Grant Date -
Dec 25, 2003
app pub date -
Mar 17, 2003
filing date -
Sep 18, 2001
priority date (Note) -
Expired
status (Latency Note)
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Abstract
A benzimidazole derivative of formula (1): ##STR1## (wherein R represents a hydrogen atom or a methoxy group, and n is 0 or 1) or a salt thereof; and a medicament containing the same. The compounds of the present invention, due to minimized difference in therapeutic effect between subjects, which difference would otherwise be derived from different CYP2C19 activity from subject to subject, ensure that all patients can enjoy proper therapeutic effects at the same dose of the drug. Also, the compounds of the invention have low risk of drug interaction caused by induction of CYP1A family member enzymes, as well as low risk of development of cancer, and thus is useful as a remedy for peptic ulcer, reliably providing therapeutic effects with safety.
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