Core-shell particle including signal-generating substance enclosed therein and process for producing the same
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United States of America Patent
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Apr 19, 2005
Grant Date -
Sep 2, 2004
app pub date -
Dec 1, 2003
filing date -
May 30, 2001
priority date (Note) -
Expired
status (Latency Note)
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Abstract
A core-shell particle including a signal-generating substance therein, wherein the core-shell particle consists of (1) a core portion substantially made of a water-insoluble polymer compound; and (2) a shell portion substantially made of a water-soluble polymer compound having a reactive functional group, and covering a surface of the core portion in the manner of bristles of a brush; and the core portion and the shell portion are, as a whole, a block copolymer of a water-insoluble polymer and a water-soluble polymer, characterized in that the signal-generating substance is included in the core portion, is disclosed, and a process for producing the same is also disclosed. The core-shell particle including a signal-generating substance therein is useful as a labeling substance in which neither radioisotopes having handling restrictions nor unstable enzymes are required, a high sensitivity superior to fluorescent substances is achieved, and nonspecific absorption does not occur.
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