Methods and compositions for efficient gene transfer using transcomplementary vectors
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United States of America Patent
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Apr 5, 2005
Grant Date -
Apr 11, 2002
app pub date -
May 31, 2001
filing date -
May 31, 2000
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Abstract
The invention includes a viral vector method and composition comprising transcomplementary replication incompetent viral vectors, preferably adenoviral vectors, which are cotransformed to a recipient cell. The two vectors complement each other and thus allow viral replication, in a synergistic combination which enhances both gene delivery and gene expression of genetic sequences contained within the vector.
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