Mini-proinsulin, its preparation and use

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United States of America Patent

PATENT NO 6875589
SERIAL NO

08402394

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Abstract

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A mini-proinsulin, in which the amino acid Arg bridges the A and the B chain instead of the C chain, shows insulin activity and is suitable for the preparation of pharmaceuticals for the treatment of diabetes mellitus. It can furthermore be converted into an insulin derivative simply using trypsin, the B chain of which is lengthened by Arg. This can be converted into insulin using carboxypeptidase B. Advantageously, however, the mini-proinsulin can also be converted to insulin directly in a one-pot process.

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Patent Owner(s)

Patent OwnerAddress
HOECHST AKTIENGESELLSCHAFT65926 FRANKFURT AM MAIN

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Dorschug, Michael Bochum, DE 10 299
Habermann, Paul Eppstein/Taunus, DE 46 702
Seipke, Gerhard Hofheim am Taunus, DE 16 346
Uhlmann, Eugen Glashutten/Taunus, DE 106 2598

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