Process for the synthesis of atorvastatin form v and phenylboronates as intermediate compounds
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United States of America Patent
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Mar 15, 2005
Grant Date -
Apr 15, 2004
app pub date -
Jul 16, 2003
filing date -
Jan 19, 2001
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Abstract
The present invention discusses a novel process for the synthesis of [R-(R*,R*)]-2-(4-fluorophenyl)-B,D-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid hemi calcium, atorvastatin. The compound so prepared is useful as inhibitor of the HMG-CoA reductase and may thus be used as hypolipidemic and hypocholesterolemic agent.
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