Bi-laminar, hyaluronan coatings with silver-based anti-microbial properties
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United States of America Patent
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Mar 15, 2005
Grant Date -
Jun 6, 2002
app pub date -
Aug 29, 2001
filing date -
Aug 30, 2000
priority date (Note) -
Expired
status (Latency Note)
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Abstract
An article including a surface having a coating thereon, in which the coating includes a base coat, firmly adhered to the surface, and a hydrophilic, biocompatible top-coat. An antibiotic ceramic component is dispersed in one or both of the base coat and top-coat. Preferably, the ceramic component is dispersed in the base coat. In a preferred embodiment, the ceramic component is a zeolite with silver ions exchanged onto internal acidic sites of the zeolite, and the top-coat includes a polysaccharide, such as hyaluronan. The zeolite is highly effective in imparting anti-microbial character to the coating.
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