2-Ureido-thiazole derivatives, process for their preparation, and their use as antitumor agents
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United States of America Patent
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Mar 8, 2005
Grant Date -
Oct 2, 2003
app pub date -
Apr 30, 2001
filing date -
Oct 30, 1998
priority date (Note) -
Expired
status (Latency Note)
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Abstract
Compounds which are 2-ureido-1,3-thiazole derivatives of formula (I) wherein R is a halogen atom, a nitro group, an optionally substituted amino group or it is a group optionally further substituted, selected from: i) straight or branched C.sub.1 -C.sub.6 alkyl; ii) C.sub.3 -C.sub.6 cycloalkyl; iii) aryl or arylalkyl with from 1 to 6 carbon atoms within the straight or branched alkyl chain; R.sub.1 is an optionally substituted group selected from: i) straight or branched C.sub.1 -C.sub.6 alkyl; ii) 3 to 6 membered carbocycle or 5 to 7 membered heterocycle ring; iii) aryl or arylcarbonyl; iv) arylalkyl with from 1 to 6 carbon atoms within the straight or branched alkyl chain; R.sub.2 is hydrogen, a straight or branched C.sub.1 -C.sub.6 alkyl or C.sub.2 -C.sub.4 alkenyl or alkynyl group; or, taken together with the nitrogen atom so which they are bonded, R.sub.1 and R.sub.2 form a substituted or unsubstituted group selected from: i) an optionally benzocondensed or bridged 5 to 7 membered heterocycle; or ii) a 9 to 11 membered spiro-heterocyclic compound; or a pharmaceutically acceptable salt thereof; are useful for treating cell proliferative disorders associated with an altered cell dependent kinase activity.
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