Transcriptional intermediary factor-2
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United States of America Patent
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Mar 1, 2005
Grant Date -
Aug 8, 2002
app pub date -
Apr 26, 2001
filing date -
Jul 12, 1996
priority date (Note) -
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Abstract
The present invention concerns a nuclear receptor (NR) transcriptional mediator. More specifically, isolated nucleic acid molecules are provided encoding transcriptional intermediary factor-2 (TIF2). Recombinant methods for making TIF2 polypeptides are also provided as are TIF2 antibodies. Screening methods are also provided for identifying agonists and antagonists of the activation function AF-2 of nuclear receptors, for identifying agonists and antagonists of the AD1 activation domain activity of TIF2, and for identifying agonists and antagonists of the AD2 activation domain activity of TIF2.
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