Stabilization of solid thyroid drug formulations
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United States of America Patent
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Feb 15, 2005
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app pub date -
Oct 18, 2000
filing date -
Oct 3, 2000
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Abstract
Pharmaceutical formulations and dosage forms are provided having improved stability to moisture-induced degradation when compared with conventional dosage forms, especially tablets. The invention features low compression forms of thyroid drugs together with excipients, preferably in encapsulated forms. In other embodiments, relatively non-volatile oils can be admixed with the drug and/or the excipients to stabilize the formulation toward moisture-induced degradation. Hydrophobic powders are also optionally added to the formulations.
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