Substituted indoles as alpha-1 agonists
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United States of America Patent
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Feb 8, 2005
Grant Date -
Nov 27, 2003
app pub date -
Jan 31, 2003
filing date -
Feb 1, 2002
priority date (Note) -
Expired
status (Latency Note)
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Abstract
This invention relates to compounds which are alpha-1 receptor agonists, preferably alpha-1A/L receptor agonists, and which are represented by Formula I: ##STR1## wherein X is --S(O).sub.n -- or --C(O)--, A is C.sub.1-6 alkyl, aryl, heteroaryl, hydroxyalkyl, or --(CH.sub.2).sub.p --NR.sup.a R.sup.b, and the other substituents are as defined in the specification; or individual isomers, racemic or non-racemic mixtures of isomers, or pharmaceutically acceptable salts or solvates thereof. The invention further relates to pharmaceutical compositions containing such compounds, methods for their use as therapeutic agents, and methods of preparation thereof.
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