Phenylsulphonylipiperazinyl derivatives as 5-HT receptor ligands
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United States of America Patent
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Feb 8, 2005
Grant Date -
Sep 25, 2003
app pub date -
Apr 21, 2003
filing date -
Mar 31, 2000
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Expired
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Abstract
A class of phenylsulphonyl derivatives wherein the sulphonyl moiety is also attached to an N-arylalkyl-substituted piperazine ring are selective antagonists of the human 5-HT.sub.2A receptor and are therefore useful as pharmaceutical agents, especially in the treatment and/or prevention of adverse conditions of the central nervous system, including schizophrenia and other psychotic disorders.
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