Agents useful for inactivation of Ras subfamily proteins
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United States of America Patent
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Feb 1, 2005
Grant Date -
Jun 5, 2003
app pub date -
Jul 31, 1998
filing date -
Feb 2, 1996
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Expired
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Abstract
A method of treating a disorder characterized by an activating mutation in a Ras proto-oncogene, comprising contacting cells of a patient suffering from the disorder with a protein having the toxic activity of Clostridium sordellii toxin LT under conditions favoring inactivation of Ras by glucosylation of Ras' threonine 35 in said cell. The protein preferably is an immunotoxin that contains as a toxic domain the catalytic domain of toxin LT.
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