Inhibitors of serine protease activity, methods and compositions for treatment of viral infections
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United States of America Patent
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Feb 1, 2005
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N/A
app pub date -
Mar 3, 2000
filing date -
Mar 5, 1999
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Abstract
A novel method of treating and preventing viral infection is provided. In particular a method of blocking viral infection facilitated by a serine proteolytic (SP) activity is disclosed, which consists of administering to a subject suffering or about to suffer from viral infection a therapeutically effective amount of a compound having a serine protease inhibitory or serpin activity. Among compounds are .alpha..sub.1 -antitrypsin (AAT), peptide derivatives from the carboxyterminal end of AAT, and man-made, synthetic compounds mimicking the action of such compounds. The preferred viral infections include retroviral infection such as human immunodeficiency virus (HIV) infection.
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