Microfluidic chip for biomolecule crystallization
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United States of America Patent
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Feb 1, 2005
Grant Date -
Mar 11, 2004
app pub date -
Dec 23, 2002
filing date -
Sep 9, 2002
priority date (Note) -
Expired
status (Latency Note)
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Abstract
A system for crystallizing a protein and other biomolecules comprises a flow channel for conveying a solution containing the biomolecule to be crystallized and one or more substations related to the crystallization process formed along the flow channel. The system operates by flowing a biomolecule solution through a the flow channel, then performing dialysis on a micro-scale to set crystallization conditions. After dialysis, the concentration of the biomolecule solution is changed by removing water or solvent from the biomolecule solution to promote formation of crystals in a segment of the flow channel. Formed crystals may be observed and harvested from the flow channel.
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