Methods of inhibition using glycosyl sulfotransferase-3
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United States of America Patent
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Jan 18, 2005
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N/A
app pub date -
Nov 8, 2001
filing date -
Mar 20, 1998
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Expired
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Abstract
A novel human glycosylsulfotransferase expressed in high endothelial cells (GST-3) and polypeptides related thereto, as well as nucleic acid compositions encoding the same, are provided. The subject polypeptides and nucleic acid find use in a variety of applications, including research, diagnostic, and therapeutic agent screening applications. Also provided are methods of inhibiting selectin mediated binding events and methods of treating disease conditions associated therewith, particularly by administering an inhibitor of at least one of GST-3 or KSGal6ST, or homologues thereof
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