Method of preparing optically pure (R)- or (S)- tetrahydrofuranyl ketone
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United States of America Patent
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Jan 11, 2005
Grant Date -
Jun 19, 2003
app pub date -
Nov 8, 2002
filing date -
Dec 4, 2001
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Expired
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Abstract
Disclosed is a method of preparing an optically pure (R)- or (S)-tetrahydrofuranyl ketone. By such a method, (R)- or (S)-2-tetrahydrofuran amide is converted to (R)- or (S)-2-tetrahydrofuran nitrile through dehydration in the presence of a dehydrating agent and an amine base. Then, thus prepared (R)- or (S)-2-tetrahydrofuran nitrile is nucelophilic addition-reacted with a nucleophile, followed by hydrolyzing, thereby produce (R)- or (S)-tetrahydrofuranyl ketone having high optical purity, while minimizing production of other by-products.
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