Transcription factor E2F DNA-binding domain inhibitor peptides and their use
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United States of America Patent
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Jan 11, 2005
Grant Date -
Jan 16, 2003
app pub date -
Jul 26, 2001
filing date -
Jan 26, 1999
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Expired
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Abstract
The present invention provides peptides which bind to the DNA binding domain of transcription factor E2F, and inhibit cell cycle progression. Peptides include FWLRFT (SEQ ID NO:1); WVRWHF (SEQ ID NO:2); WHFIFW (SEQ ID NO:3); IWLSGLSRGVWVSFP (SEQ ID NO:4); and GSRILTFRSGSWYAS (SEQ ID NO:5) and derivatives based upon these sequences. Compositions and the use of the peptides in inhibiting cell cycle progression, such as in uncontrolled cell proliferation, are also provided.
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