Degradable polymers

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United States of America Patent

PATENT NO 6828412
SERIAL NO

10069929

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Abstract

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A polymer comprising: a polymeric backbone comprising at least one unit having the structure (I), wherein R-R.sup.4 comprise groups selected from the group consisting of H, C.sub.1 -C.sub.12 alkyl, C.sub.6 -C.sub.18 aryl, C.sub.7 -C.sub.18 aralkyl, C.sub.6 -C.sub.18 cycloalkyl or any of the group consisting of C.sub.1 -C.sub.12 alkyl, C.sub.6 -C.sub.18 aryl, C.sub.7 -C.sub.18 aralkyl, C.sub.6 -C.sub.18 cycloalkyl substituted, within the carbon chain or appended thereto, with one or more heteroatoms; R and R.sup.2 or R and R.sup.4 or R and R.sup.1 or R.sup.2 and R.sup.3 may be joined so that with the carbon atom(s) to which they are attached they together form a saturated, partially unsaturated or unsaturated ring system respectively, may have a pendent group which may incorporate a linker unit, (for example a peptide linkage) or a unit having the structure (I); A comprises a proton donating moiety selected from the group consisting of formula (1). B comprises a hydrolytically labile group and is selected from the group consisting of formula (2), wherein each R.sup.5 is individually selected from the group consisting of H, C.sub.1 -C.sub.12 alkyl, C.sub.6 -C.sub.18 aryl, C.sub.7 -C.sub.18 aralkyl, C.sub.6 -C.sub.18 cycloalkyl; wherein groups A and B are in a cis-configuration about bond C.sub.a --C.sub.b ; m is an integer of 0 to 100, n, p and q are each an integer of 0 or 1; Q comprises 1 or more structures selected from the group consisting of formula (3) wherein R.sup.6 -R.sup.11 are individually selected from the same group as defined for group R above and r is an integer between 1 and 5000, preferably 1 to 10, most preferably 1 to 6; methods for the production, and uses thereof.

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Patent Owner(s)

Patent OwnerAddress
POLYTHERICS LIMITEDBABRAHAM CAMBRIDGE CB22 3AT

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Brocchini, Stephen James London, GB 18 327
Clochard, Marie-Claude Dubois London, GB 1 11

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