Hydroxy and amine functionalized resins
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United States of America Patent
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Dec 7, 2004
Grant Date -
May 22, 2003
app pub date -
Aug 28, 2001
filing date -
Aug 28, 2001
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Abstract
A star-blocked polymeric material based on polyethylene glycol and having a uniform distribution of both hydroxy and amine functional groups throughout the polymeric material is described. The polymeric material, known as HYDRA (hydroxy and amine functionalized resin), is prepared by forming a polyimine compound by reacting an aldehyde and an amine. The polyimine is then reacted with a reducing agent to form a star-blocked polymeric material. HYDRA resins can be used, for example, as solid supports for organic synthesis, for enzymatic assays, for immobilization of biomolecules, for controlled release of drugs, and for chromatographic separations.
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